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Data-centric AI approach to Out-of-distribution problems in Life Sciences

What the AI Co-Scientist Paper Actually Demonstrates for Biologists and Data Scientists

January 22, 2026
9 AM PST/ 12:00 PM EST

Standard AI models rely on the assumption that real-world data matches training patterns (IID). However, in the complex landscape of biology, this assumption frequently breaks. Valuable signals such as unexpected drug responses or rare patient profiles, often appear as "Out-of-Distribution" (OOD) data, which traditional models struggle to interpret. Join Elucidata’s team as we present a data-centric AI framework designed to navigate these challenges. We will explore why "data is the hero" and how prioritizing data quality over model size is essential for reliable performance in the "long tail" of scientific discovery. The session will focus on three key pillars for solving OOD problems:

  • High-quality Data Infrastructure: Fueling models with clean, linked, and context-rich data to improve performance on rare, small-sample problems.
  • Federated Learning: Leveraging decentralized training to learn from diverse, private datasets and handle distributional shifts.
  • Physics-based Rules: Integrating first principles to help models reason beyond their training corpus.

The webinar will also explore AI tools like Ultra Deep Research, highlight how we build and deploy various AI agents, share real-world lessons from the field, and feature insights on dealing with OOD outliers into the next generation of innovation.

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Meet the Expert of this discussion
Abhishek Jha
Co-founder & CEO, Elucidata
Nobal Dhruv
Director Research & ML, Elucidata
Manimala Sen
Director Technical Product Management, Elucidata

Real-World Applications We’ll Cover

  • Scaling clinico-genomic data integration: Large pharmaceutical organizations working with external data providers used Polly to build interoperable clinico-genomic data products 6x faster.
    Although purchased datasets are often labeled as "clean," they still lack interoperability—Polly's pipelines bridge this gap with robust integration and harmonization.

  • Information Retrieval: Drug safety monitoring teams used Polly's Knowledge Graph powered co-scientist to conversationally retrieve the right cohorts & assess drug response—cutting discovery time by 70%.

Register now
Join us for a behind-the-scenes look at a Multi-agent AI system that achieves:
  • 93% recall across 23 key metadata fields including tissue, disease, cell line, donor ID, and treatment.
  • Outperformance of GPT-4.1 single-pass prompting on accuracy, F1 score, and traceability.
  • Curation of 4652 samples from 78 GEO datasets in days instead of weeks.
  • 4x reduction in manual effort equivalent to replacing a 3-person expert team working for 1 month.
  • Human-level accuracy, with 100% concordance on disease and 97% on gender based on CellxGene benchmarks.
  • Traceable records with field-level evidence attribution and confidence scores.
Register for our webinar to see how the Agentic AI system fits into scalable data workflows.

What You’ll Learn

This session gives biomedical researchers and data scientists the practical steps to build stronger, more reliable AI for drug discovery.

  • The IID vs. OOD Reality Check:
    • Understand exactly why standard AI fails when faced with real-world patient differences and rare biology (OOD data).
    • Learn how ignoring OOD signals leads to wasted R&D effort and missed breakthrough opportunities.
  • The 3 Data-Centric AI Pillars:
    • Data-Centric AI ensures biological reliability by using accurate context to eliminate noise, decentralized access to capture global diversity, and scientific laws to keep predictions physically grounded.
  • Introducing Elucidata AI Labs:
    • Explore how AI Labs moves beyond static training to support continuous learning from dynamic, real-world biological data.
    • See how Elucidata automates data harmonization and quality checks, empowering your team to make confident discovery and development decisions.
Register now
Meet the Expert of this discussion
Abhishek Jha
Co-founder & CEO, Elucidata
Nobal Dhruv
Director Research & ML, Elucidata
Manimala Sen
Director Technical Product Management, Elucidata
Meet the Expert of this discussion
Abhishek Jha
Co-founder & CEO, Elucidata
Nobal Dhruv
Director Research & ML, Elucidata
Manimala Sen
Director Technical Product Management, Elucidata
What Sets polly KG Apart
Natural language querying with reasoning on
the roadmap
Cross-species graphs built from both proprietary
and public data
Custom scoring logic and domain-specific
ontology support
Seamless integration with internal tools, platforms,
and security frameworks
Who Should Attend
Translational Scientists and Discovery Leads
Computational Biologists and Data Scientists
Platform Owners, heads of R&D IT
Innovation and AI Strategy Teams
Who Should Attend
Translational Scientists and Discovery Leads
Data Science & Informatics Teams
Computational Biologists and R&D IT Leaders
Innovation & AI Strategy Teams

Why This Matters for Biomedical Researchers

Adopting a Data-Centric and OOD-aware approach is essential for delivering real therapeutic impact.

If you’re working with complex biological data, you may be asking:

  • Can generative AI truly assist in scientific reasoning, not just data analysis?

  • What does it mean for hypothesis generation, literature review, or even designing experiments?

  • Could this accelerate—not replace—my discovery pipeline?

Whether you're skeptical, curious, or already experimenting with AI in your lab—this is a session designed to ground your understanding in evidence, not speculation.

  • Unlock Breakthroughs in the "Outliers"
    • The most valuable discoveries hide in the rare, unexpected data points (OOD). Learn to harness these signals instead of discarding them, driving innovation in areas like non-responders and novel targets.
  • Build Models You Can Trust Clinically
    • Models trained to handle OOD data are fundamentally more robust and reliable. This means fewer late-stage failures and more confidence in your go/no-go decisions for drug candidates.
  • Maximize Your Data Investment
    • Stop wasting time and money cleaning data. By focusing on quality and context (Data-Centric AI), you dramatically increase the predictive power of every expensive data point you generate.
  • Accelerate Research with an AI-Ready Platform
    • Elucidata AI Labs provides the clean, linked, and scalable data infrastructure that frees your scientists to focus on high-value model building and critical scientific analysis, not data wrangling.

Traditional KG

  • Unlock Breakthroughs in the "Outliers"
    • The most valuable discoveries hide in the rare, unexpected data points (OOD). Learn to harness these signals instead of discarding them, driving innovation in areas like non-responders and novel targets.
  • Build Models You Can Trust Clinically
    • Models trained to handle OOD data are fundamentally more robust and reliable. This means fewer late-stage failures and more confidence in your go/no-go decisions for drug candidates.
  • Maximize Your Data Investment
    • Stop wasting time and money cleaning data. By focusing on quality and context (Data-Centric AI), you dramatically increase the predictive power of every expensive data point you generate.
  • Accelerate Research with an AI-Ready Platform
    • Elucidata AI Labs provides the clean, linked, and scalable data infrastructure that frees your scientists to focus on high-value model building and critical scientific analysis, not data wrangling.

Polly KG

Register now
Meet the Experts of this discussion
Abhishek Jha
Co-founder & CEO, Elucidata
Nobal Dhruv
Director Research & ML, Elucidata
Manimala Sen
Director Technical Product Management, Elucidata
Harshveer Singh
Director Engineering Research & Development, Elucidata
Key Takeaways
How data providers ensure adherence to quality standards through validation and compliance.
How GUI-based workflows, CLI tools, and collaborative workspaces enable streamlined data ingestion and synchronization at scale.
Understand how automated pipelines assess conformance, plausibility, and consistency, ensuring high-quality, AI-ready data products.
Key Takeaways
Reduce operational costs by streamlining data delivery through reusable, governed products.
Accelerate diagnostic development and clinical trial execution by delivering compliant, high-quality data at scale.
Improve audit readiness and regulatory confidence through governed data products and built-in quality assurance.
Equip cross-functional teams to act on trusted data—faster, and with greater confidence.
Who Should Attend
Translational Scientists and Discovery Leads
Computational Biologists and Data Scientists
Platform Owners, heads of R&D IT
Innovation and AI Strategy Teams
What Sets polly KG Apart
First KG to integrate molecular data alongside patient data records
Feature distillation pipeline for high-dimensional clinical and trial data
Base KG usable immediately, with flexible schema extensions
Cross-species graphs built from proprietary, public, and clinical datasets
Who Should Attend?

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