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AI-Powered Insights from PK/PD Clinical Trial Data

PK/ PD teams need to find competitive intel on drugs from clinical trial reports. Our multi-agentic AI enables these analysis much faster.

What the AI Co-Scientist Paper Actually Demonstrates for Biologists and Data Scientists

August 28, 2025
10:30 AM PST / 1:30 PM EST

When developing drugs - for example, those designed to cross the blood–brain barrier to treat CNS disorders - development teams need to know how competing drugs are performing in the market. This competitive intelligence often lies buried in vast volumes of clinical trial publications.

The current process involves - Manually reviewing trial reports, extracting data from PDFs, and converting unstructured information into usable tables. By the time this process is completed and the data is ready, the opportunity to act on insights may already be lost.

With a multi-agentic AI approach, Polly Xtract automates the extraction and structuring of PK/PD data from clinical trial reports.

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Meet the Expert of this discussion
Hatim Zariwala
Faculty, Boston University, Ex- Head of CNS Research at Stealth Biotherapeutics
Shubhra Agrawal
Senior Scientific Manager, Elucidata

Real-World Applications We’ll Cover

  • Scaling clinico-genomic data integration: Large pharmaceutical organizations working with external data providers used Polly to build interoperable clinico-genomic data products 6x faster.
    Although purchased datasets are often labeled as "clean," they still lack interoperability—Polly's pipelines bridge this gap with robust integration and harmonization.

  • Information Retrieval: Drug safety monitoring teams used Polly's Knowledge Graph powered co-scientist to conversationally retrieve the right cohorts & assess drug response—cutting discovery time by 70%.

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Join us for a behind-the-scenes look at a Multi-agent AI system that achieves:
  • 93% recall across 23 key metadata fields including tissue, disease, cell line, donor ID, and treatment.
  • Outperformance of GPT-4.1 single-pass prompting on accuracy, F1 score, and traceability.
  • Curation of 4652 samples from 78 GEO datasets in days instead of weeks.
  • 4x reduction in manual effort equivalent to replacing a 3-person expert team working for 1 month.
  • Human-level accuracy, with 100% concordance on disease and 97% on gender based on CellxGene benchmarks.
  • Traceable records with field-level evidence attribution and confidence scores.
Register for our webinar to see how the Agentic AI system fits into scalable data workflows.

What You’ll Learn

  • Live Demo – See Polly Xtract process trial reports and output structured PK/PD datasets, ready for analysis
  • Developing PK/ PD Intel from clinical trials
  • How Xtract supports custom data models, including OMOP, FHIR, and internal schemas
  • Why Polly Xtract outperforms generic LLMs for complex biomedical documents
  • How auto-schema extraction unlocks trial arms, endpoints, and inclusion/exclusion criteria in minutes
  • How PK/PD data on BBB-penetrating drugs can be extracted and modeled at scale

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Meet the Expert of this discussion
Hatim Zariwala
Faculty, Boston University, Ex- Head of CNS Research at Stealth Biotherapeutics
Shubhra Agrawal
Senior Scientific Manager, Elucidata
What Sets polly KG Apart
Natural language querying with reasoning on
the roadmap
Cross-species graphs built from both proprietary
and public data
Custom scoring logic and domain-specific
ontology support
Seamless integration with internal tools, platforms,
and security frameworks

Why This Matters for Biomedical Researchers

If you’re working with complex biological data, you may be asking:

  • Can generative AI truly assist in scientific reasoning, not just data analysis?

  • What does it mean for hypothesis generation, literature review, or even designing experiments?

  • Could this accelerate—not replace—my discovery pipeline?

Whether you're skeptical, curious, or already experimenting with AI in your lab—this is a session designed to ground your understanding in evidence, not speculation.

Traditional KG

Polly KG

Register now
Meet the Expert of this discussion
Hatim Zariwala
Faculty, Boston University, Ex- Head of CNS Research at Stealth Biotherapeutics
Shubhra Agrawal
Senior Scientific Manager, Elucidata
Key Takeaways
How data providers ensure adherence to quality standards through validation and compliance.
How GUI-based workflows, CLI tools, and collaborative workspaces enable streamlined data ingestion and synchronization at scale.
Understand how automated pipelines assess conformance, plausibility, and consistency, ensuring high-quality, AI-ready data products.
Key Takeaways
Reduce operational costs by streamlining data delivery through reusable, governed products.
Accelerate diagnostic development and clinical trial execution by delivering compliant, high-quality data at scale.
Improve audit readiness and regulatory confidence through governed data products and built-in quality assurance.
Equip cross-functional teams to act on trusted data—faster, and with greater confidence.
Who Should Attend
Translational Scientists and Discovery Leads
Computational Biologists and Data Scientists
Platform Owners, heads of R&D IT
Innovation and AI Strategy Teams
Who Should Attend?

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