A vast amount of biological multi-omics data is generated worldwide at any given point; this data has enormous potential for discovery and reusability for various R&D projects. However, the increasing volume and complexity of handling omics data go hand-in-hand. One of the challenges with analyzing and interpreting omics data is extracting meaningful insights from large-scale and high-dimensional data sets from multiple sources. Making sense of omics data requires advanced methods of data reduction and visualization techniques that can only be achieved with powerful data analytics tools, methods, and software. There is a lack of good practice pertaining to software and database usage which is the main source of computational irreproducibility, especially while analyzing very large datasets. Even the smallest variations across computational platforms contribute to irreproducibility. Handling pipelines, a large number of software packages, and dealing with hundreds of intermediate files produced by individual tools are some of the many difficulties. Hardware fluctuations in these types of pipelines, combined with poor error handling could result in considerable readout instability.
A solution designed to address numerical instability, efficient parallel execution, error tolerance, execution provenance, and traceability is Nextflow. Nextflow is a workflow management system that uses Docker technology for the multi-scale handling of containerized computation. It is a domain-specific language that enables reproducible and parallel processing of pipelines.
Interesting, right? Continue to read this blog to know how we use it on Polly to handle pipelines effectively, saving both cost and time.
We hope you found this blog useful! If you have any questions on how we use Nextflow in Polly or would like to know more about Polly, reach out to us and we will be happy to answer them!
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