Our ‘Dataset of the Week’ series features publicly available omics datasets of scientific value, intending to promote data sharing and reuse.
This week’s dataset is from the publication titled ‘Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection’.
SARS-CoV-2 is known to induce cardiac complications in some patients, in addition to its well-established respiratory symptoms. The aim of this paper was to examine the effects of SARS-CoV-2 on cardiomyocytes and cardiac function.
This dataset contains bulk RNA-seq data derived from hiPSC-CMs infected with SARS-CoV-2 and corresponding controls. It could serve as a useful resource to study cardiomyocyte-specific effects of SARS-CoV-2 and elucidate the molecular mechanisms that lead to cardiac complications such as arrhythmias and cardiac failure.
hiPSC-CMs were infected with 0.1 MOI SARS-CoV-2 or serum-free media (control) for 72 hours and harvested for bulk RNA-seq (3 biological replicates per group).
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