CASE STUDY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Key Highlights

  • Glutamine deprivation affects M2 polarization but not M1 Polarization
  • UDP-GlcNAc biosynthesis and N-glycosylation are important for M2 polarization
  • There is no reverse or direct flow through Idh or malic enzyme in M1 macrophages
  • Aspartate-arginosuccinate shunt connects the NO and TCAcycles in M1 polarization

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