Polly delivers the highest quality Bulk RNA-seq datasets to fit diverse analysis methods & pipelines. All datasets are Polly Verified, i.e. harmonized with a configurable, granular & transparent curation process.
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Customize the processing pipeline used, metadata fields annotated, or ontologies applied to fit unique analysis fields.
Request additional curation of cohort-based comparisons within bulk RNA-seq datasets. Every comparison comprises pre-computed differential expression results to streamline your search for biologically relevant signatures.
Our experts implement ~50 QA checks to perform batch effect correction, metadata validation, and remove technical artifacts & variations in every dataset.
The data normalization methods or QC metrics used on Polly are not a black box. Learn how each Bulk RNA-seq dataset was processed by downloading a detailed QA/QC report from Polly.
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Perform gene, pathway, or metadata-based queries to find and explore the data you need.
Utilize interactive volcano plots, heatmaps, and more to visualize enriched genes and pathways.
Stream Polly harmonized Bulk RNA-seq datasets to your preferred tools for advanced analyses.
We use at least 50+ QA checks to ensure every dataset is:
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Data validation checks ensure that all dataset and sample-level metadata annotations contain non-NULL and non-blank values.
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Rigorous QC checks to ensure metadata attributes are human-readable and accurately assigned
at all levels (dataset, cell).
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Normalization and batch Effect correction are applied wherever necessary to eliminate technical variations and enable meaningful comparisons between samples.
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Doublets, which can arise during sample preparation and confound
analysis, are identified
and removed.
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Poor-quality samples, genes, and cohorts are filtered out. Genes that drive biological variation are retained and used for downstream analyses.
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