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De-risking Translational Strategy with Agentic AI

What the AI Co-Scientist Paper Actually Demonstrates for Biologists and Data Scientists

September 18, 2025
10:30 AM PST / 1:30 PM EST

Before you enter Phase 1 clinical trials, your biggest lever is knowing where not to go. Currently, integrating Phase 1 evidence is a messy and slow challenge, so translational teams lack a simple, reliable way to benchmark their drug candidate - and often compare against an incomplete picture and hence risk losing out on time.

Across therapeutic areas, drug development still faces a big gap, early evidence sits across many trials and formats, making it hard to compare a new candidate with what’s already been tried. Without a clear benchmark, choices on patient cohorts, biomarkers, and trial design recommendations take longer and lean on subjective judgment - and once an IND is set, changing course is costly.

This webinar shows a practical way to de-risk your plan. We’ll use Inflammatory Bowel Disease (IBD) clinical trials as a live use case to walk through the whole journey. You’ll see how Polly Xtract’s agentic AI workflow to turn comparator drugs’ Phase 1 reports into a single, source-linked dataset. You’ll see apples-to-apples benchmarks and simple tables that highlight which subtypes to avoid, which to prioritize, and how to design a Phase 1 that’s set up to show signal - before decisions harden.

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Meet the Expert of this discussion
Devan Moodley
Head of Translational Sciences (ex-Abata)
Sachin Kumar Gupta
Senior Scientific Manager, Elucidata

Real-World Applications We’ll Cover

  • Scaling clinico-genomic data integration: Large pharmaceutical organizations working with external data providers used Polly to build interoperable clinico-genomic data products 6x faster.
    Although purchased datasets are often labeled as "clean," they still lack interoperability—Polly's pipelines bridge this gap with robust integration and harmonization.

  • Information Retrieval: Drug safety monitoring teams used Polly's Knowledge Graph powered co-scientist to conversationally retrieve the right cohorts & assess drug response—cutting discovery time by 70%.

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Join us for a behind-the-scenes look at a Multi-agent AI system that achieves:
  • 93% recall across 23 key metadata fields including tissue, disease, cell line, donor ID, and treatment.
  • Outperformance of GPT-4.1 single-pass prompting on accuracy, F1 score, and traceability.
  • Curation of 4652 samples from 78 GEO datasets in days instead of weeks.
  • 4x reduction in manual effort equivalent to replacing a 3-person expert team working for 1 month.
  • Human-level accuracy, with 100% concordance on disease and 97% on gender based on CellxGene benchmarks.
  • Traceable records with field-level evidence attribution and confidence scores.
Register for our webinar to see how the Agentic AI system fits into scalable data workflows.

What You’ll Learn

  • How to “data-scout” Phase 1 IBD publications and posters to assemble a clean precedent set for your target population.
  • Live Demo - How Polly Xtract structures evidence (dose, exposure, endpoints, safety, inclusion/exclusion) with clickable provenance for every value.
  • How to benchmark your asset against comparator programs using aggregated Phase 1 outcomes - side-by-side.
  • How AI agents propose strategy intelligently, including: cohort selection and stratification, subtypes to exclude, feasible biomarker panels, and endpoint choices you can defend.
  • Operationalization & review, i.e., how to package outputs for internal gates (IND/Protocol Review) and respond to regulatory questions with traceable evidence.
Register now
Meet the Expert of this discussion
Devan Moodley
Head of Translational Sciences (ex-Abata)
Sachin Kumar Gupta
Senior Scientific Manager, Elucidata
What Sets polly KG Apart
Natural language querying with reasoning on
the roadmap
Cross-species graphs built from both proprietary
and public data
Custom scoring logic and domain-specific
ontology support
Seamless integration with internal tools, platforms,
and security frameworks

Why This Matters for Biomedical Researchers

If you’re working with complex biological data, you may be asking:

  • Can generative AI truly assist in scientific reasoning, not just data analysis?

  • What does it mean for hypothesis generation, literature review, or even designing experiments?

  • Could this accelerate—not replace—my discovery pipeline?

Whether you're skeptical, curious, or already experimenting with AI in your lab—this is a session designed to ground your understanding in evidence, not speculation.

  • Enter Phase 1 smarter. Use real precedents to pick cohorts and biomarkers that are more likely to show signal; avoid subtypes that consistently underperform.
  • Fewer amendments, faster cycles. Evidence-backed choices reduce protocol churn and downstream rework.
  • Regulatory-grade traceability. Every decision links to the exact sentence, table, or figure it came from - simplifying QA, IRB, and regulatory queries.
  • Fair comparisons, less bias. Normalize endpoints and definitions across studies to get objective, apples-to-apples benchmarks.
  • Reusable data product. One curated corpus can support adjacent assets and future indications, cutting ramp time for new programs and partners.

Traditional KG

  • Enter Phase 1 smarter. Use real precedents to pick cohorts and biomarkers that are more likely to show signal; avoid subtypes that consistently underperform.
  • Fewer amendments, faster cycles. Evidence-backed choices reduce protocol churn and downstream rework.
  • Regulatory-grade traceability. Every decision links to the exact sentence, table, or figure it came from - simplifying QA, IRB, and regulatory queries.
  • Fair comparisons, less bias. Normalize endpoints and definitions across studies to get objective, apples-to-apples benchmarks.
  • Reusable data product. One curated corpus can support adjacent assets and future indications, cutting ramp time for new programs and partners.

Polly KG

Register now
Meet the Expert of this discussion
Devan Moodley
Head of Translational Sciences (ex-Abata)
Sachin Kumar Gupta
Senior Scientific Manager, Elucidata
Key Takeaways
How data providers ensure adherence to quality standards through validation and compliance.
How GUI-based workflows, CLI tools, and collaborative workspaces enable streamlined data ingestion and synchronization at scale.
Understand how automated pipelines assess conformance, plausibility, and consistency, ensuring high-quality, AI-ready data products.
Key Takeaways
Reduce operational costs by streamlining data delivery through reusable, governed products.
Accelerate diagnostic development and clinical trial execution by delivering compliant, high-quality data at scale.
Improve audit readiness and regulatory confidence through governed data products and built-in quality assurance.
Equip cross-functional teams to act on trusted data—faster, and with greater confidence.
Who Should Attend
Translational Scientists and Discovery Leads
Computational Biologists and Data Scientists
Platform Owners, heads of R&D IT
Innovation and AI Strategy Teams
Who Should Attend?

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