Technology · Polly Knowledge Graph

Polly KG: Your Knowledge Graph Is Only as Good as Its Evidence.

Elucidata grades every gene-disease relationship as supporting, contradicting, or neutral before it becomes a KG edge, because co-occurrence alone does not tell you which direction the evidence points.

3x

Faster hypothesis generation vs. prior workflows

8M+

Full-text articles processed, into methods and supplementary sections

3

Evidence grades per relationship: supporting, contradicting, or neutral

Technology · Polly Knowledge Graph

Polly KG: Your Knowledge Graph Is Only as Good as Its Evidence.

Elucidata grades every gene-disease relationship as supporting, contradicting, or neutral before it becomes a KG edge, because co-occurrence alone does not tell you which direction the evidence points.

3x

Faster hypothesis generation vs. prior workflows

8M+

Full-text articles processed, into methods and supplementary sections

3

Evidence grades per relationship: supporting, contradicting, or neutral

What target ID teams achieved

What target ID teams achieved

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Cross-species KG · comparative genomics biotech

3x

Faster hypothesis generation

Polly KG graded cross-species relationships before the shortlist was built, separating supporting from contradicting evidence across hundreds of candidates
Multi-modal dataset audit · comparative benchmark

#1

Candidate advanced to Phase 1

Elucidata's evidence package covered ~10 AML hypotheses. The candidate with the highest qualified evidence score on the shortlist advanced to Phase 1.
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Technology

Here's how the Evidence Layer works

D/L Type I
HIPAA compliant
AES-256 at rest and in transit
Dedicated AWS VPC

What This Enables in Target ID

Once the knowledge graph is built on direction-graded evidence, your target selection has something to stand on.

Validation-ready evidence — KG-Based Target Validation.

The same knowledge graph that ranked candidates requalifies them at the validation stage. Contradicting evidence noted at ranking becomes a validation gate.

From 20,000 genes to investment-ready targets.

Custom scoring across disease relevance, druggability, and proprietary signal. Delivered in production for COPD, metabolic disease, and complement biology programs.

Foundation for Spatial / GWAS / Patient Stratification programs.

Atlas supplies the pre-harmonized data that Cohorter queries. Cohort construction starts from clean, ontology-mapped records.

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Part of the Elucidata service offering

Polly Scout powers the data discovery phase of Elucidata's Data Partner service, and is the first step in every Program Partner engagement where evidence completeness determines shortlist quality.

KG-Based Target Ranking & Co-Build

The primary program type. Elucidata processes 8M+ full-text papers and qualifies every gene-disease relationship as supporting, contradicting, or neutral before writing a KG edge. Every edge carries direction and confidence. Delivered in production for COPD, metabolic disease, and AML programs.

KG-Based Target Validation

The same qualified evidence layer used for target ranking requalifies relationships at the validation stage. Delivered in production for complement-mediated disease programs.

Gene Disease Target Assessment

Polly KG is available as an optional evidence layer in Gene Disease Target Assessment engagements, supplying the biomedical knowledge graph that Polly Lens scores against.

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How Scout integrates into your program

We integrate Scout into your stack in the model that fits your program. Elucidata handles the run; your team works with the results.

Polly UI

Web interface for KG exploration, target scoring dashboards, and evidence report generation via Polly Lens.

KG MCP Server

The KG MCP Server connects your AI tooling directly to Polly KG. List graphs, run Cypher, download results. In production as of Q2 2026.

APIs

We wire Polly KG into your stack via the Polly KG REST API, with Cypher and natural language queries supported and async execution for large result sets.

Co-Scientist

Guided AI research interface for querying the KG, exploring mechanisms, and generating evidence reports without writing queries. Also available via Slack integration.

Full API documentation and integration guides available on request.

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FAQs

Questions From Every Evaluation Call

What is the difference between a co-occurrence knowledge graph and a qualified biomedical knowledge graph?

Co-occurrence counts how often a gene and disease appear together. Polly's KG separates supporting from contradicting evidence before writing any edge. For target identification in drug discovery, that distinction determines which candidates make the shortlist.

What is the difference between KG-Based Target Ranking & Co-Build and KG-Based Target Validation?

Target Ranking narrows 20,000 genes to a ranked shortlist using the knowledge graph. Target Validation uses the same qualified evidence to stress-test specific candidates before wet-lab commit. Both use direction-graded evidence. The question changes: 'who should we pursue?' versus 'does this candidate hold up?'

How does Polly KG support target identification in drug discovery?

The Polly Knowledge Graph gives your scoring layer direction-graded evidence, not raw co-occurrence counts. Candidates with mixed or contradicting evidence are flagged before they reach the shortlist.

Can the knowledge graph handle rare targets or thin literature?

Yes. Full-text processing recovers evidence from supplementary sections and methods text that abstract-only tools miss. Proprietary in-house datasets go through the same qualification pipeline as public literature.

How often is the knowledge graph updated?

PubMed Central literature is ingested continuously. Proprietary data integrates at program milestones.

What stage of target discovery does Polly KG support?

The full range, from initial target discovery through target validation. The same KG that ranks 20,000 genes also carries the contradicting evidence your team needs at the validation stage.

How does AI-driven drug discovery benefit from Polly KG?

AI models that query a co-occurrence graph amplify noise. Polly KG gives AI models qualified, direction-graded inputs, so your models start from defensible evidence.

Your target ID program needs data you can defend.
Let us find it.