Our ‘Dataset of the Week’ series features publicly available omics datasets of scientific value, intending to promote data sharing and reuse.
This week’s dataset includes metabolomics data from the publication titled 'Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice', published in Cell (May 2019).
Autism spectrum disorder (ASD) affects approximately 1 in 54 individuals in the USA. Clinical symptoms of ASD cover a wide range of behavioral, learning, and locomotory impairments. Preliminary lines of evidence have indicated differences in the distribution of gut flora between typically developing (TD) and ASD-affected individuals. This publication used fecal transplants from ASD patients to determine how the gut microbiome and metabolic profile contribute to symptom development in mice.
This dataset contains metabolomics data from the blood plasma and colon contents of TD and ASD humanized mice. Researchers studying the role of the gut-brain axis in the context of autism spectrum disorders and behavioral deficits will potentially benefit from this resource.
Human fecal samples from TD or ASD affected individuals and were transplanted into C57BL6 mice (n=15 TD, n= 20 ASD). Colon contents and blood plasma from both groups of mice were extracted and metabolomics analysis was carried out by LCMS and NMR.
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